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KMID : 0617219910020010059
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Duksung Bulletin Phamaceutical Sciences
1991 Volume.2 No. 1 p.59 ~ p.67
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Pharmacological Studies of Methanol Extract of the Cortex of Ulmus davidiana var.japonica
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Abstract
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The barks of Ulmus daviana var. japonica(Ulmaceae) has been described in Dongeueibogam written by Joon Huh to have diuretic and laxative actions, to amliorate edematous disease, and to be used in insomnia and gastrointestinal disorders. Thus this study was carried out to elucidate some of the pharmacological activities of the plant extracts. From the results obtained it was identified that is methanol extract elicited remarkable inhibition of HCI · ethanol induced gastric lesion, of gastric secretion and of gastric Shay ulceration. However, it showed neither sedative nor antiinflammatory actions. The acute toxicity of the extract was low, that is, the minimum lethal dose was more than 2000mg per kg by oral administration in mice. The systematic fractionation of the methanol extract by hexane, ether, ethylacetate and butanol resulted in potent prevention of gastric lesion and ulceration in butanol and water fractions.
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